The danger-profit ratio of using flumazenil in benzodiazepine overdose is influenced because of the presence of an underlying risk of seizures and the dose employed. Administering flumazenil inside the presence of proconvulsant coingestants (eg, anticholinergics, stimulants, cyclic antidepressants) may be perhaps destructive mainly because it will

Also, bradycardia Long lasting almost 72 hours indicates a chronic half-life of flubromazolam in step with the literature. Thinking about the small half-life of flumazenil, comparatively, a number of repeat doses would have been important to elicit only A brief effect. Other outstanding documented qualities ended up loss of Command (resulting in

Sad to say, there are no conventional “therapeutic” concentrations of flubromazolam that may be correlated with clinical manifestations in the predictable way. A single situation report4 has proposed that serum flubromazolam concentrations of forty three ng/mL may lead to cardiorespiratory failure. This individual, nonetheless, documented inges

The more quickly performing routes of administration were being frequently utilised by flubromazolam people aiming to receive “high” or “squandered”, instead of usually utilized by the “self-medicating” end users. Flubromazolam very likely has a lower toxicity relative to dose. Even so, it's likely lethal when combined with depres

Occasional reports also described how flubromazolam was utilized to cope with, or to break, manic episodes. Several people noted greater Strength concentrations as well as a pleasurable lessening of inhibition as ideal effects. Regretably, there won't be any normal “therapeutic” concentrations of flubromazolam that could be correlated with m